APG-115 Size:Contact [email protected] for quotation 4-b]azepin-3-yl]-5-phenyl-5H

4-b]azepin-3-yl]-5-phenyl-5H

¹⁶]heptadeca-1

Solubility: DMSO : ≥ 125 mg/mL (416

Schirrmacher E

Smiles: CN1CCC(CNC2=CC(=NC3=CC(OCCCN4CCCC4)=C(C=C32)OC)C2=CC=C(C)O2)CC1

APG-115 Size:Contact [email protected] for quotation 4-b]azepin-3-yl]-5-phenyl-5HAPG 115 (AA 115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3. 8 nM and 1 nM, respectively. APG 115 blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53 dependent manner. Product information CAS Number: 1818393 16 6 Molecular Weight: 642. 59 Formula: C34H38Cl2FN3O4 Chemical Name: 4 {[(3'R,4'S,5'R) 6'' chloro 4' (3 chloro 2 fluorophenyl) 1' ethyl 2'' oxo 1'',2''