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Solubility: DMSO: 89 mg/mLwarmed(183
and 25 mg/kg prolongs median survival to 19
61(15):6801-6813
Molecular Weight: 530
431(1):119-25
AEE788 60258 Solubility: DMSO: 89 mg/mLwarmed(183AEE 788 is an orally bioavailable multiple receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor associated endothelial cell apoptosis. Check for
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