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E-7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2
van Kampen RJ
AGI-5198 has good cellular activities in TS603 glioma cell line
After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC50 >10 μM
10(5):481-2
AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 E-7449 is a potent PARP1AZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7